The β-Hydroxybutyrate (BHB) test from Cardinal Health is an FDA-approved method for early detection of clinically significant ketosis. The test is specific for BHB, the main ketone body produced during ketosis (78%), and is available on over 30 chemistry analyzer platforms. Available for use with serum or plasma samples, the test method is based on quantitative enzymatic detection that ensures accuracy for BHB. During ketosis, BHB increases more than the levels of acetone and acetoacetate; this method provides a tool for determining and monitoring this condition.