The new Thermo Scientific Mass Spectrometric Immunoassay (MSIA) pipette tips from Thermo Fisher Scientific are a collection of immunoaffinity sample preparation products. The robust MSIA technology delivers a simplified way to enrich target proteins for downstream mass spectrometric analysis. MSIA tips feature a 300-μl pipette tip embedded with a proprietary, highly porous immunoaffinity column that provides increased sensitivity with improved reproducibility and sample throughput. Benefits include enhanced antibody/antigen-binding kinetics that allow enrichment down to very low levels (femtomoles) for downstream mass spectrometric protein/peptide quantification; as well as improved signal-to-noise ratios due to increased specificity and target recovery as compared to conventional bead-based methods; and fast and flexible sample throughput with manual multichannel or fully automated 96-well processing in less than 30 minutes.