Roche’s cobas Respiratory 4-flex is an FDA-cleared, multiplex PCR test designed to detect and differentiate SARS-CoV-2, Influenza A, Influenza B, and RSV in a single run. Compatible with Roche’s cobas 5800, 6800, and 8800 systems, the 4-flex assay offers customizable syndromic testing tailored to physician orders and patient needs. The assay includes an optional digital reflex function, allowing labs to report additional targets from the same sample based on clinical relevance, helping to streamline workflows and reduce unnecessary repeat testing. Powered by Roche’s TAGS (temperature-activated generation of signal) technology, 4-flex is designed to deliver accurate, efficient respiratory testing that helps laboratories optimize operational efficiency while supporting diagnostic stewardship.