The enhanced version of Liquichek Opiate Control from Bio-Rad Laboratories includes updated fentanyl target levels optimized for clinically relevant cutoffs across major chemistry analyzer platforms. This versatility helps laboratories meet evolving testing requirements with confidence, accuracy, and precision. The system contains eight opioid drugs or drug metabolites, at concentrations above and below assay cutoffs as recommended by the US Substance Abuse and Mental Health Services Administration (SAMHSA), other agencies, and reagent manufacturers. Designed to improve workflows and deliver validated precision at clinically relevant cut-offs, Liquichek can empower laboratories to confidently report results and strengthen their ability to respond to the opioid crisis.