Bruker Corporation launches the timsTOF Ultra 2 system, featuring enhanced sensitivity for deep profiling of small cells, subcellular organelles, and increased sample loading flexibility. Together with new Spectronaut 19 software and the PreOmics ENRICHplus kit, Bruker’s OmniScape software offers top-down sequence confirmation and de novo sequencing for intact, undigested proteoforms, dissociated in the mass spectrometer. The timsTOF Ultra 2 is designed to help labs investigate immune homeostasis, surveying low abundance proteins from small peripheral blood mononuclear cells (PBMCs), or from bacterial cells comprising the microbiome, or for immunopeptidomics to discover cancer neoantigens from fine needle biopsies. New ion charge control (ICC2.0) software provides sample loading flexibility from low picogram amounts to about a microgram of protein digest.