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April 2019

Therapeutic Drug Monitoring Antibodies

By: Bio-Rad Laboratories, Inc

Bio-Rad Laboratories has launched a range of recombinant monoclonal anti-idiotypic antibodies that inhibit the binding of the drug eculizumab (Soliris) to its target, complement C5 protein, and therefore detect free drug for use in drug-level monitoring assays. This new range comprises four inhibitory antibodies that are highly specific for the humanized IgG2/4 kappa monoclonal antibody drug, eculizumab, a biotherapeutic used to treat paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. The anti-eculizumab inhibitory antibodies can be used to quantify the level of eculizumab in patient samples. An antibody pair is ideal for the development of a pharmacokinetic bridging ELISA, and three antibodies of high, medium, and low affinity are suitable as a positive control or calibrator in an anti-drug antibody assay.

Bio-Rad Laboratories, Inc

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