The Association for Molecular Pathology (AMP) has released recommendations to support and facilitate sharing of variant data through public repositories. This series of recommendations has been designed to help achieve better diagnostic testing, treatments, and therapies, with the goals of enhancing patient care and advancing the field of precision medicine. Despite the current availability of public databases, multiple recommendations, and calls to action, as well as some incentives for contribution, participation in data sharing among clinical laboratories remains low. AMP’s recommendations are intended to make it easier for labs to participate in data sharing programs to help improve this important collaboration.